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Endocarditis symptoms may develop slowly or suddenly. How fast it develops depends on the type of infection and associated risk factors. Common symptoms are fever, chills, weakness and aching joints/muscles. Other symptoms may include: new heart murmur; night sweats; shortness of breath; paleness; persistent cough; swelling in feet, legs, or abdomen; unexplained weight loss; blood in urine; tenderness in spleen; Osler’s nodes (red, painful nodes in the pads of fingers and toes); and Janeway lesions (red painless skin spots on the palms and soles).