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Jason A. Castellanos, MD, MS, FACS

Jason A. Castellanos
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  • Assistant Professor, Department of Surgical Oncology

Specialties

Surgical Oncology, Hepatobiliary and Pancreatic Surgery

Distinctions
2025 Top Doctors by Philadelphia magazine Emblem for High Performing Hospitals for Colon Cancer Surgery 2024-2025
5
153 Patient Satisfaction Ratings
About Me
Ratings & Reviews
Publications
About Me
Education
  • Fellow in Hepatopancreaticobiliary Surgery, Memorial Sloan Kettering Cancer Center, New York, NY - 2019-2020
  • Fellow in Complex General Surgical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY - 2018-2020
  • Master of Science - Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN - 2014-2016
  • Categorical Resident in General Surgery, Vanderbilt University School of Medicine, Nashville, TN - 2009-2018
  • Doctor of Medicine, Vanderbilt University School of Medicine, Nashville, TN - 2005-2009
  • Bachelor of Arts - Sociology, Stanford University, Stanford, CA - 2002-2004
  • United States Military Academy, West Point, NY - 2000-2002
Board Certifications
  • American Board of Preventive Medicine - Clinical Informatics
  • American Board of Surgery
  • American Board of Surgery - Surgery
Memberships
  • American College of Surgeons, 2009-Present
  • Association for Academic Surgery, 2011-Present
  • American Pancreatic Association, 2012-Present
  • Pancreas Club, 2013-2016
  • American Association of Cancer Research, 2014-Present
  • American Medical Informatics Association
  • Society of Surgical Oncology, 2015-Present
Awards and Honors
  • 2024-25 - Philadelphia Magazine Top Doctors, Surgery
  • 2017 - Administrative Chief Resident, General Surgery Residency, Vanderbilt University Medical Center – Department of Surgery
  • 2016 - Academic Surgical Congress Research Award, Society of Asian Academic Surgeons
  • 2016 - Outstanding Resident Research Award, Basic Science, Association of Academic Surgeons
  • 2013 - Kenneth Warren Research Award, Pancreas Club
  • 2012 - Best Resident Cancer Paper, Tennessee Chapter of the American College of Surgeons
  • 2009 - Levi Watkins Jr. Student Award for Commitment to Diversity, Vanderbilt University School of Medicine
  • 2009 - H. William Scott Society Prize in Surgery, Vanderbilt University School of Medicine
  • 2009 - Alpha Omega Alpha
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  • Philadelphia Magazine Top Doctors, 2024
  • 2017 - Administrative Chief Resident, General Surgery Residency, Vanderbilt University Medical Center – Department of Surgery
  • 2016 - Academic Surgical Congress Research Award, Society of Asian Academic Surgeons
  • 2016 - Outstanding Resident Research Award, Basic Science, Association of Academic Surgeons
  • 2013 - Kenneth Warren Research Award, Pancreas Club
  • 2012 - Best Resident Cancer Paper, Tennessee Chapter of the American College of Surgeons
  • 2009 - Levi Watkins Jr. Student Award for Commitment to Diversity, Vanderbilt University School of Medicine
  • 2009 - H. William Scott Society Prize in Surgery, Vanderbilt University School of Medicine
  • 2009 - Alpha Omega Alpha
Ratings & Reviews

The following ratings and reviews are based on verified feedback collected from independently administered patient experience surveys. The ratings and comments submitted by patients reflect their own views and opinions. Patient identities are withheld to ensure confidentiality and privacy. Learn more about our Patient Experience Ratings.

Ratings Breakdown

Overall Care
5.0
Explained Things Clearly
5.0
Showed Courtesy & Respect
5.0
Discussed Treatment Options
5.0
Recommend Provider
5.0

Patient Comments

5 out of 5 (153 ratings, 29 comments)
07/29/2024

Dr. Castellanos and his team were excellent throughout the lead up to my surgery, my hospital stay and the follow up visit.

07/16/2024

Dr. Castellanos was great. He was professional, efficient, informative but above all personable. He showed great concern for my medical issue and instilled confidence for a complete recovery. His PA [...] was fabulous to work with. He was concerned, listened to ME, and acted accordingly. He was personable and put me at ease each visit I had with him. I would highly recommend this office to anyone who may need the type of services I needed.

07/15/2024

Dr Castellanos, hands down, the best physician I have EVER met. His knowledge of medicine and clear concern for the patient is worthy of the highest praise. During the many appts I have had with him, I immediately felt at ease and know he has my best care and understanding of my case. He's absolutely in the top 1%!

06/19/2024

My diagnosis was scary, but Dr. Castellanos made me feel secure!

06/16/2024

Dr. Castellanos was the best in explaining my upcoming surgery. He and his nurse [...] made me feel comfortable and understood answering all my questions and concerns.

Offices

Office Locations

Fox Chase Cancer Center

333 Cottman Avenue

Philadelphia, PA 19111

Phone: 888-369-2427

Publications
Publications

Dosch, Austin R., Xizi Dai, Alexander A. Gaidarski Iii, Chanjuan Shi, Jason A. Castellanos, Michael N. VanSaun, Nipun B. Merchant, and Nagaraj S. Nagathihalli. “Src Kinase Inhibition Restores E-Cadherin Expression in Dasatinib-Sensitive Pancreatic Cancer Cells.” Oncotarget 10, no. 10 (February 1, 2019): 1056–69. https://doi.org/10.18632/oncotarget.26621. PMID: 30800218.

Totiger, Tulasigeri M., Supriya Srinivasan, Venkatakrishna R. Jala, Purushottam Lamichhane, Austin R. Dosch, Alexander A. Gaidarski, Chandrashekhar Joshi, Shobith Rangappa, Jason A. Castellanos, Praveen Vemula, Xi Chen, Deukwoo Kwon, Nilesh Kashikar, Michael VanSaun, Nipun Merchant, and Nagaraj Nagathihalli. “Urolithin A, a Novel Natural Compound to Target PI3K/AKT/MTOR Pathway in Pancreatic Cancer.” Molecular Cancer Therapeutics 18, no. 2 (February 1, 2019): 301–11. https://doi.org/10.1158/1535-7163.MCT-18-0464. PMID: 30404927.

Srinivasan, Supriya, Tulasigeri Totiger, Chanjuan Shi, Jason A. Castellanos, Purushottam Lamichhane, Austin R. Dosch, Fanuel Messaggio, et al. “Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer.” Cancer Research 78, no. 21 (November 1, 2018): 6146–58. https://doi.org/10.1158/0008-5472.CAN-180579. PMID: 30232221.

Nagathihalli, Nagaraj S., Jason A. Castellanos, Purushottam Lamichhane, Fanuel Messaggio, Chanjuan Shi, Xizi Dai, Priyamvada Rai, Xi Chen, Michael N. VanSaun, and Nipun B. Merchant. “Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer.” Cancer Research 78, no. 21 (November 1, 2018): 6235–46. https://doi.org/10.1158/0008-5472.CAN-18-0634. PMID: 30154150.

Messaggio, Fanuel, Alisha M. Mendonsa, Jason A. Castellanos, Nagaraj S. Nagathihalli, Lee Gorden, Nipun B. Merchant, and Michael N. VanSaun. “Adiponectin Receptor Agonists Inhibit Leptin Induced PSTAT3 and in Vivo Pancreatic Tumor Growth.” Oncotarget 8, no. 49 (October 17, 2017): 85378–91. https://doi.org/10.18632/oncotarget.19905. PMID: 29156726.

Kummerow Broman, Kristy, Christianne L. Roumie, Melissa K. Stewart, Jason A. Castellanos, John L. Tarpley, Robert S. Dittus, and Richard A. Pierce. “Implementation of a Telephone Postoperative Clinic in an Integrated Health System.” Journal of the American College of Surgeons 223, no. 4 (2016): 644–51. https://doi.org/10.1016/j.jamcollsurg.2016.07.010. PMID: 2754510.

Nagathihalli, Nagaraj S., Jason A. Castellanos, Michael N. VanSaun, Xizi Dai, Mahogany Ambrose, Qiaozhi Guo, Yanhua Xiong, and Nipun B. Merchant. “Pancreatic Stellate Cell Secreted IL-6 Stimulates STAT3 Dependent Invasiveness of Pancreatic Intraepithelial Neoplasia and Cancer Cells.” Oncotarget 7, no. 40 (October 4, 2016): 65982–92. https://doi.org/10.18632/oncotarget.11786. PMID: 27602757.

Walsh, Alex J., Jason A. Castellanos, Nagaraj S. Nagathihalli, Nipun B. Merchant, and Melissa C. Skala. “Optical Imaging of Drug-Induced Metabolism Changes in Murine and Human Pancreatic Cancer Organoids Reveals Heterogeneous Drug Response.” Pancreas 45, no. 6 (2016): 863–69. https://doi.org/10.1097/MPA.0000000000000543. PMID: 26495796.

Nagathihalli, Nagaraj S.*, Jason A. Castellanos*, Chanjuan Shi, Yugandhar Beesetty, Michelle L. Reyzer, Richard Caprioli, Xi Chen, et al. “Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.” Gastroenterology 149, no. 7 (December 2015): 1932-1943.e9. https://doi.org/10.1053/j.gastro.2015.07.058. PMID: 26255562. *Co-first authors.

Guo Q, Ambrose M, Yugandhar Beesetty, Jason A. Castellanos, Nagaraj Nagathihalli, Nipun Merchant. IL-6 secreted from pancreatic stellate cells activates STAT3 and promotes cell growth and invasive ability of pancreatic cancer. Young Scientist. 2014; 4:63-65.

Castellanos, Jason A., and Nipun B. Merchant. “Intensity of Follow-up after Pancreatic Cancer Resection.” Annals of Surgical Oncology 21, no. 3 (March 2014): 747–51. https://doi.org/10.1245/s10434-013-3289-7. PMID: 24092447.

Castellanos, Jason A., Christina M. Edwards, Aaron Shaver, Nipun B. Merchant, and Alexander A. Parikh. “Appendiceal Adenocarcinoma Presenting as Venous Thromboembolism: An Unusual Presentation of a Rare Carcinoma.” The American Surgeon 76, no. 5 (May 2010): 543–44. PMID: 20506889.

Merchant, Nipun B., Jennifer Rymer, Elizabeth A. S. Koehler, G. Daniel Ayers, Jason A. Castellanos, David A. Kooby, Sharon H. Weber, et al. “Adjuvant Chemoradiation Therapy for Pancreatic Adenocarcinoma: Who Really Benefits?” Journal of the American College of Surgeons 208, no. 5 (May 2009): 829–38; discussion 838-841. https://doi.org/10.1016/j.jamcollsurg.2008.12.020. PMID: 19476845.