Multiple media outlets, including KYW, Medical Xpress and Genetic Engineering & Biotechnology News highlighted research conducted by The Wistar Institute; Nathaniel W. Snyder, PhD, MPH, Associate Professor in the Aging + Cardiovascular Discovery Center at the Lewis Katz School of Medicine at Temple University; and collaborators at other institutions that was published in Nature. The researchers uncovered a potential target to debilitate the DNA repair in a subset of cancers (including ovarian cancers) and overcome treatment resistance. For the first time, these researchers have shown a new metabolic process is altered in cancer cells that makes them resistant to DNA-damaging agents. The findings also point to an existing drug to inhibit this pathway as a promising strategy to break through chemotherapy resistance.
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