Lisa Rae, MD, FACS, Chief of Burn Surgery, provided perspective to the Bulletin, the monthly magazine of the American College of Surgeons, about the severity of skin wounds associated with xylazine and treatment protocols. Xylazine, which is also known as Tranq, is an animal sedative that has been increasingly found in fentanyl and heroin and causes fast-moving, severe, necrotic wounds and heavy sedation. These wounds can cause amputations and may resemble necrotizing fasciitis.