Daniel A. Salerno, MD, MS, Director of Critical Care Services in the Respiratory ICU at Temple University Hospital and Professor of Clinical Thoracic Medicine & Surgery at the Lewis Katz School of Medicine at Temple University, provided perspective to Medscape on new guidelines presented at the American College of Chest Physicians (CHEST) Annual Meeting in Chicago and published in CHEST, on red blood cell transfusions for critically ill patients. Dr. Salerno was not involved in the new guidelines.