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Pathology & Laboratory Medicine

Yuri Persidsky, MD, PhD

Yuri Persidsky



about me
about me
Clinical Interests
  • Surgical pathology
  • Nephropathology
  • Administration of clinical laboratories
Research Interests
  • Molecular mechanisms regulating functions of blood brain barrier under physiologic and pathologic conditions (neuroinflammation, HIV-1 brain infection, alcohol and drug abuse)
  • Pericyte dysfunction in blood brain barrier impairment caused by HIV infection
  • Biomarkers of blood brain barrier injury
  • Neuroprotective strategies based on diminution of neuroinflammation and blood brain barrier injury
  • Effects of cannabinoids on neural stem cells
  • PhD, Pathology, Kiev Research Institute of Urology and Nephrology, Ukrainian Ministry of Health, Kiev, Ukraine
  • MD, Bogomolets National Medical University, Kiev, Ukraine
  • Residency, Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
Board Certification
  • Anatomic Pathology
  • College of American Pathologists
  • American Society of Clinical Pathologists
  • American Society for Investigative Pathology
  • Society for NeuroImmune Pharmacology
Awards and Honors
  • MERIT grant, National Institute on Alcohol Abuse and Alcoholism, 2010-2020
  • Wybran award, Society on Neuroimmune Pharmacology, 2011

Research Projects

  • Blood brain barrier injury in HIV infection complicated by diabetes: Mechanisms and protective strategies preventing cognitive impairment
  • CNS injury caused by HIV-1 and alcohol: Protective effects of cannabinoid receptor 2 activation
  • HIV-induced neuroinflammation associated with opioid abuse and tobacco smoke
  • Secoisolariciresinol diglucoside to mitigate inflammation and toxicity in HIV associated dementia

Office Locations

Temple University Hospital – Main Campus

3401 N. Broad Street

Philadelphia, PA 19140


Digital Bibliography

Persidsky Y, Steffan AM, Gendrault JL, Berger S, Royer C, Hurtrel B, Stutte HJ, Aubertin AM, Kirn A: Involvement of liver sinusoidal cells at different stages of simian immunodeficiency virus (SIV) infection in macaques. In: Cells of the Hepatic Sinusoid, vol 5, Wisse, Knook, Wake, eds, Kupffer Cell Foundation, Leiden. The Netherlands. 1995; 33-36.

Persidsky Y, Steffan AM, Gendrault JL, Royer C, Aubertin AM, Kirn A: Morpho-functional changes of follicular dendritic cells (FDC) and lymph node structure in simian immunodeficiency virus (SIV) infection. In: Dendritic Cells in Fundamental and Clinical Immunology. Banchereau and Schmitt, eds, Plenum Press, New York. 1995; 329-331.

Persidsky Y, Gendelman HE: HIV-1 encephalitis is a consequence of viral infection and immune activation. In: Biology and Physiology of the Blood Brain Barrier (Couraud, Sherman, eds.), Plenum Press, New York, 1996; 365-367.

Persidsky Y, Tyor W: Nontransgenic murine animal model systems for the HIV-associated cognitive motor complex. In: Neurological and Neuropsychiatric Manifestations of HIV-1 Infection, Gendelman HE, Lipton S, Epstein L, Swidells S, eds. Chapman & Hall Publishers, NY 1997, pp. 168-178.

Gendelman HE, Ghorpade A, Persidsky Y: The neuropathogenesis of HIV-1 dementia. In: In Defense of the Brain, Peterson, Remington (eds.), Blackwell Sci, 1997, 290-304.

Persidsky, Y. Murine animal model systems for studies of HIV-1-associated dementia. In: The Neurology of AIDS, 2nd Edition. Gendelman HE, Grant I, Lipton SA, Everall IP, Swindells S. (Eds.). Oxford University Press, 2005, p. 289-296.

Persidsky Y. NeuroAIDS. In: Neuroimmune Pharmacology. Ikezu T, Gendelman HE, Kabanov AV, Pahan K, Pseborski S. (Eds). Springer, NY. 2008. 297-312.

Haorah J, Floreani NA, Persidsky Y. Alcohol-induced blood-brain barrier dysfunction. In: Research on the Neurobiology of Alcohol Use Disorders. Sher L. (Ed.). Nova Science Publishers, New York, 2008. p.239-260.

Persidsky Y, Ramirez SH. The blood-brain barrier in the setting of neuroinflammation. In: The Neurology of AIDS, 3rd Edition. Gendelman, H.E., Grant, I., Lipton, S.A., Everall, I.P. and Swindells, S. (Eds.). Oxford University Press, 2011, p. 220-230.

Persidsky Y, Ho WZ, Wang X, Potula R. Alcohol Abuse, HIV-1 and Hepatitis C Infection. Chapter 11. Neuro-Immune Effects of Alcohol. Springer. 2012, p. 509-534.

Persidsky Y, Gofman L, Potula R. Alcohol and Neurodegeneration. Chapter 24. Book “Neuroinflammation and Neurodegeneration”. Edited by Peterson PK and Toborek M. 2014, pp.511-528.

Merkel S, Ramirez SH, Persidsky Y. Blood brain barrier (BBB) dysfunction in HIV Infection. Chapter 3, Volume II Book “The Blood-Brain Barrier in Health and Disease”. 2015. Edited by Dorovini-Zis, K. CRC Press, Francis and Taylor.