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Xiaojin Sha, MD, PhD

Xiaojin Sha

  • Assistant Professor, Clinical Pathology and Laboratory Medicine, Lewis Katz School of Medicine at Temple University

About Me
Publications
About Me
Clinical Interests
  • Cytopathology
  • Breast pathology
  • Gynecologic pathology
Research Interests
  • Tumor suppressor in cancer cell proliferation and differentiation
  • Vascular inflammation
Education
  • MD, Tianjin Medical University, China
  • PhD, Molecular Biology, Humboldt University of Berlin, Germany
Training
  • Fellowship, Women’s Pathology (Breast Pathology and Gynecology Pathology), NYU Langone Health, New York, NY
  • Fellowship, Cytopathology, Thomas Jefferson University Hospital, Philadelphia, PA
  • Residency, Pathology, University of Toledo Medical Center, Toledo, OH
Memberships
  • American Society of Cytopathology (ASC)
  • College of American Pathologists (CAP)
Offices

Office Locations

Publications
Publications

1. Daniyah A. Almarghalani, Xiaojin Sha, Robert E. Mrak and Zahoor A. Shah*. Spatiotemporal Cofilin Signaling, Microglial Activation, Neuroinflammation, and Cognitive Impairment Following Hemorrhagic Brain Injury. Cells 2023, 12, 1153.

2. Li XY, Sha Y, Sha XJ, Fang P, Kuo YM, Andrews AJ, Li YF, Yang WY, Maddaloni M, Pascual DW, Luo JJ, Jiang XH, Wang H, Yang XF. IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14). Arterioscler. Thromb. Vasc. Biol. (2018);38:599-609

3. Sha XJ, Hoffman B, Liebermann DA. Loss of Gadd45b accelerates BCR-ABL-driven CML. Oncotarget, 2018 Sep 7;9(30):33360-3336

4. Mukherjee K*, Sha XJ*, Magimaidas A*,Skorski T, Bhatia R, Hoffman B, Liebermann DA. Gadd45a deficiency accelerates BCR-ABL driven chronic myelogenous leukemia. Oncotarget, 2017 Feb 14;8(7):10809-10821.(*co-first authors)

5. Malfrede S, Magimaidas A, Sha XJ, Mukherjee K, Liebermann DA. Hoffman B. Loss of Eg1, a human del5q gene, accelerates BCR-ABL driven chronic myelogenous leukemia. Oncotarget, 2017 Sep 19;8(41):69281-69294.

6. Sha XJ, Meng S, Li XY, Xi H, Maddaloni M, Pascual DW, Wang H, Yang XF. Novel cytokine interleukin-35 inhibits endothelial cell activation by suppressing MAPK-AP1-mediated VCAM-1 expression. J.Biol.Chem. 2015, July; 290(31): 19307-18

7. Yin Y, Li XY*, Sha XJ*, Xi H*, Mai JT, Virtue A, Lopez-Pastrana J, Meng S, Tilley D, Monroy MA, Choi ET, Thomas CJ, Jiang XH, Wang H, Yang XF. (*co-second authors). Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway. Arterioscler. Thromb. Vasc. Biol. (2015), April:35(4):804-16

8. Li XY, Mai JT, Virtue A, Yin Y, Gong R, Sha XJ, Gutchingian X, Frisch A, Hodge I, Jiang XH, Wang H, Yang XF. IL-35 is a novel responsive anti-inflammatory cytokine- a new system of categorizing anti-inflammatory cytokines. PLOS ONE. 2012, 7 (3): 1-13.

9. Cretu A, Sha XJ, Tront J, Hoffman B, Liebermann DA. Stress sensor Gadd45 genes as therapeutic targets in cancer. Cancer Therapy. 2009, 7: 268-276.

10. Müller C, Calkhoven CF, Sha XJ and Leutz A. The CCAAT enhancer-binding protein α (C/EBPα) requires a SWI/SNF complex for proliferation arrest. (2004) J.Biol.Chem. 279,7353-7.

11. Sha XJ, Song YH, Rao Q, Lin YM, Zhu XF, Wu, KW. The level of soluble macrophage colony stimulating factor receptor in children with hematological diseases. Journal of Leukemia. 2002,11(4): 195-1