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Lee F. Peng, MD, PhD

Lee F. Peng
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GI/Gastroenterology, Hepatology, Liver Transplant

about me
about me
Clinical Interests
  • Hepatology
  • Liver disease
  • Cirrhosis
  • Viral hepatitis
  • Hepatitis A
  • Hepatitis B
  • Hepatitis C
  • Hepatitis D
  • Hepatitis E
  • Alcoholic liver disease
  • Fatty liver disease
  • Autoimmune hepatitis
  • Primary biliary cirrhosis (PBC)
  • Primary sclerosing cholangitis (PSC)
  • Hemochromatosis
  • Wilson's disease
  • Fatty liver disease/nonalcoholic steatohepatitis (NASH)
  • Ascites
  • Varices
  • Hepatic encephalopathy
  • Endoscopy - esophagogastroduodenoscopy (EGD) and colonoscopy
Research Interests
  • Viral hepatitis
  • Chemical biology
  • Synthetic organic chemistry
  • Developmental biology
  • MD, Harvard Medical School, Cambridge, MA
  • PhD, Chemistry, Harvard University, Cambridge, MA
  • Fellowship, Gastroenterology, Massachusetts General Hospital, Boston, MA
  • Fellowship, Medicine, Harvard Medical School, Cambridge, MA
  • Fellowship (Research), Medicine, Harvard Medical School Cambridge, MA
  • Residency, Internal Medicine, Massachusetts General Hospital, Boston, MA
Board Certification
  • Gastroenterology
  • Internal Medicine
  • American Association of Study of Liver Diseases
  • American Gastroenterology Association
  • American College of Physicians
Awards and Honors
  • Liver Research Scholar, American Liver Foundation / American Association for the Study of Liver Diseases 

Office Locations

Temple Digestive Disease Center

Temple University Hospital – Main Campus

3401 N. Broad Street

Ambulatory Care Center, 3rd Floor

Philadelphia, PA 19140


Temple Health Ft. Washington

515 Pennsylvania Avenue

Fort Washington, PA 19034


Temple Pancreas & Liver Transplant Program at St. Luke’s

St. Luke's Gastroenterology

701 Ostrum Street

Suite 201

Bethlehem, PA 18015



Peng, Lee F.; Schaefer, Esperance; Maloof, Nicole; Skaff, Andrew; Berical, Andrew; Belon, Craig A.; Heck, Julie A.; Lin, Wenyu; Frick, David N.; Allen, Todd M.; Miziorko, Henry; Schreiber, Stuart L.; Chung, Raymond T. Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits HMG-CoA synthase. Journal of Infectious Disease, 2011, 204: 609-616.

Peng, Lee F.;* Stanton, Benjamin Z.;* Maloof, Nicole; Nakai, Kazuo; Wang, Xiang; Chen, James K.; Schreiber, Stuart L. Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. Bio-organic and Medicinal Chemistry Letters, 2009, 19:6319-25.

Peng, Lee F.; * Kim, Sun Suk;* Matchacheep, Sirinya; Lin, Wenyu; Choe, Won-Hyeok; Sakamoto, Naoya; Schreiber, Stuart L.; Chung, Raymond T. Identification of Novel Epoxide Inhibitors of HCV Replication Via High-Throughput Screening.