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Pathology & Laboratory Medicine

Jian Jeff Fu, MD, PhD

Jian Jeff Fu



about me
about me
Clinical Interests
  • Pathology
  • PhD, Karlsruhe University, Germany
  • MD, Shanghai Medical University, China
  • Fellowship, Surgical Pathology, Fox Chase Cancer Center, Philadelphia, PA
  • Fellowship, Hematopathology, NYU Langone Medical Center, New York, NY
  • Residency, Anatomic/clinical pathology, Hahnemann University Hospital, Philadelphia, PA
  • Postdoctoral fellow and Research Associate, Pathology, Fox Chase Cancer Center, Philadelphia, PA
  • Postdoctoral fellowship, Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA
Board Certification
  • Hematology
  • Anatomic and Clinical Pathology

Office Locations

Temple University Hospital – Main Campus

3401 N. Broad Street

Philadelphia, PA 19140


Selected Publications

1. Regulation of HIF1-α by the proprotein convertases furin and PC7 in human squamous carcinoma cells. Fu J, Zhang J, Gong Y, Testa CL, Klein-Szanto AJ. Mol Carcinog. 2015 Sep;54(9):698-706. doi: 10.1002/mc.22131. Epub 2014 Jan 16.

2. Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases. Fu J, Bassi DE, Zhang J, Li T, Cai KQ, Testa CL, Nicolas E, Klein-Szanto AJ. Neoplasia. 2013 Feb;15(2):169-79.

3. Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth. Fu J, Bassi DE, Zhang J, Li T, Nicolas E, Klein-Szanto AJ. Neoplasia. 2012 Apr;14(4):271-82.

4. Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development. Watts JA, Zhang C, Klein-Szanto AJ, Kormish JD, Fu J, Zhang MQ, Zaret KS. PLoS Genet. 2011 Sep;7(9):e1002277. Epub 2011 Sep 15.

5. VILIP-1 expression in vivo results in decreased mouse skin keratinocyte proliferation and tumor development. Fu J, Jin F, Zhang J, Fong K, Bassi DE, Lopez De Cicco R, Ramaraju D, Braunewell KH, Conti C, Benavides F, Klein-Szanto AJ. PLoS One. 2010 Apr 15;5(4):e10196.

6. Promoter regulation of the visinin-like subfamily of neuronal calcium sensor proteins by nuclear respiratory factor-1. Fu J, Zhang J, Jin F, Patchefsky J, Braunewell KH, Klein-Szanto AJ. J Biol Chem. 2009 Oct 2;284(40):27577-27586. Epub 2009 Aug 12.

7. VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival. Fu J, Fong K, Bellacosa A, Ross E, Apostolou S, Bassi DE, Jin F, Zhang J, Cairns P, Ibañez de Caceres I, Braunewell KH, Klein-Szanto AJ. PLoS One. 2008 Feb 27;3(2):e1698.

8. Proprotein convertases: "master switches" in the regulation of tumor growth and progression. Bassi DE, Fu J, Lopez de Cicco R, Klein-Szanto AJ. Mol Carcinog. 2005 Nov;44(3):151-61.

9. BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. Gonzalez EM, Reed CC, Bix G, Fu J, Zhang Y, Gopalakrishnan B, Greenspan DS, Iozzo RV. J Biol Chem. 2005 Feb 25;280(8):7080-7. Epub 2004 Dec 9.

10. Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. Bix G, Fu J, Gonzalez EM, Macro L, Barker A, Campbell S, Zutter MM, Santoro SA, Kim JK, Höök M, Reed CC, Iozzo RV. J Cell Biol. 2004 Jul 5;166(1):97-109.

11. Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. Mongiat M*, Fu J*, Oldershaw R, Greenhalgh R, Gown AM, Iozzo RV. (* Both authors contributed equally to the results of this work). J Biol Chem. 2003 May 9;278(19):17491-9. Epub 2003 Feb 25.

12. Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. Mongiat M, Sweeney SM, San Antonio JD, Fu J, Iozzo RV. J Biol Chem. 2003 Feb 7;278(6):4238-49. Epub 2002 Nov 14.

13. Effect of phorbol 12-myristate-13-acetate on cell adhesion in SMMC-7721 human hepatocellular carcinoma cell line and its mechanism. Fu J, Zha XL. J Exp Clin Cancer Res. 1998 Jun;17(2):153-7.

14. Expression of the integrin alpha5 subunit and its mediated cell adhesion in hepatocellular carcinoma. Yao M, Zhou XD, Zha XL, Shi DR, Fu J, He JY, Lu HF, Tang ZY. J Cancer Res Clin Oncol. 1997;123(8):435-40.

15. Regulation of PMA on SMMC-7721 human hepatocarcinoma cell adhesion and integrin gene expression (in Chinese). Fu J, Wang JY, Zhang YE, Zha XL. Chinese J. Biochemistry and Molecular Biology. 1998; 14 (2): 212-217. 16. The progress of integrin-mediated signal transduction (in Chinese). Fu J and Zha XL. Chemistry of Life, 1996, 16 (4): 23-26.