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Christian A. Koch, MD, PhD, FACP, MACE

Specialties

Endocrinology, Diabetes and Metabolism

about me
offices
publications
about me
Research Interests
  • Neuroendocrinology and Neuroscience
  • Pathogenesis of endocrine tumors incl. pituitary, adrenal, thyroid glands
  • Endocrine Hypertension
  • Endocrine Genetics and hormone resistance / insensitivity syndromes
  • Multiple endocrine neoplasia syndromes
  • Von Hippel Lindau syndrome
  • Adrenal tumors
  • Water metabolism and pituitary disorders (Cushing’s, acromegaly, others)
Languages
  • German
Education
  • DSc, University of Leipzig, “Dr.med.habilitatus”, Leipzig, Germany, 2003
  • Fellowship in Endocrinology, National Institutes of Health, 1998-2001
  • Internship and residency in Internal Medicine,  Ohio State University Hospitals, Columbus, OH, 1994-97
  • Honorary research scholar, Royal Children’s Hospital, Dept. of Endocrinology, Melbourne, Australia, 1996
  • USMLE Step III, USMLE Step II, 1997
  • USMLE Step I (during internship/residency in the U.S.), 1995
  • Residency in neurology, University Hospital Jena, Jena, Germany, 1993
  • PhD, Westfalian-Wilhelms-University, Muenster, Germany, 1993
  • TOEFL (English test) and ECFMG indefinitely # 0-459-402-4, 1993
  • FMGEMS, Part II (clinical sciences), 1991
  • MD,  Friedrich-Alexander University, Erlangen-Nuremberg, Germany, 1991
Memberships
  • Fellow of the American College of Physicians (ACP)
  • Master of the American College of Endocrinologists (AACE)
  • Member of the Southern Society of Clinical Investigation/SSCI
  • American Endocrine Society
  • American Diabetes Association
  • National Lipid Association
  • German Diabetes Association (DDG) and German Diabetologist “DDG”
  • German Endocrine Society
Committee Memberships
  • AACE Pituitary, Gonad, Adrenal and Neuroendocrine Disease State Network, 2018-
  • AACE Adrenal Scientific Committee (Chair: Dr. Karel Pacak), 2016-2018
  • Clinical Guidelines Subcommittee, Endocrine Society (Chair: Dr. Maria Fleseriu), 2015-2018
  • AACE (President: George Gruenberger, MD) Publications Committee, 2015-2018
  • AACE (President: George Gruenberger, MD) Awards Committee, 2015-2018
  • Southern States Chapter of AACE, Board of Directors (President: Dr. Richard Rosenthal), 2015 -2018
  • Council member, Southern Region AFMR (Execut. Dir: E. Chouinard, B. Wagner), 2013-
  • Research Committee, DoM, Univ of Miss Med Center, 2006-2008, 2009-
Awards and Honors
Philadelphia Magazine Top Docs 2020

Endocrinology, Diabetes & Metabolism
  • Philadelphia Magazine Top Doctors, 2020
  • Master of the American College of Endocrinology = M.A.C.E., 2017
  • US News Top Doctor 2011-2016
  • Castle Connolly America’s Top Doctors 2007-2016
  • The Leading Physicians of the World 2013-2016
  • Best of United States Physicians 2009 (bestofus.com)
  • Patient’s Choice Award 2013-2015
  • Compassionate Doctor Recognition 2013-2015
  • Marquis Who is Who in the World 2009, Biltmore Who’s Who 2009
  • Consultant of the Year Award, Dept of ENT (Chair: S. Stringer, MD), Univ of Mississippi, June 2008
  • O-(utstanding) professor/researcher visa in 2007 and in 2001 (see Google)
  • Winner International Poster Competition, ACP, San Diego, April 2003
  • F.A.C.P. - election in July 2002 (age 37, published academician pathway)
  • F.A.C.E. = Fellow of the American College of Endocrinology 5/2001
  • Young Investigator Award (1st place): AACE, May 2001, Texas
  • Resident outstanding teacher award, The Ohio State University, 1997
publications
Selected Publications

Gubbi S, Hannah-Shmouni F, Verbalis JG, Koch CA.Hypophysitis: an update on the novel forms, diagnosis and management of disorders of pituitary inflammation. Best Pract Res Clin Endocrinol Metab 2019;Dec 12:101371 doi: 10.1016/j.beem.2019.101371

Fulop T, Zsom L, Hamrahian M, Rodriguez RD, Chabrier-Rosello JO, Koch CA. Therapeutic hypernatremia management during continuous renal replacement therapy with elevated intracranial pressures and respiratory failure. Rev Endocr Metab Disord 2019;20 (1):65-75   

Khan AA, Koch CA, Van Uum SHM, Baillargeon JP, Bollerslev J, Brandi ML, Marcocci C, Rejnmark L, Rizzoli R, Shrayyef MZ, Thakker RV, Yildiz BO, Clarke B. Standards of care for hypoparathyroidism in adults. Eur J Endocrinol 2019,180(3):P1-P22

Koch CA, Krabbe S, Hehmke B. Statins, metformin, proprotein-convertase-subtilisin-kexin type-9 (PCSK9) inhibitors and sex hormones: immunomodulatory properties ? Rev Endocr Metab Disord 2018, Dec (19(4):363-395

Koch CA, Petersenn S. Black swans – neuroendocrine tumors of rare locations. Rev Endocr Metab Disord 2018,Jun;19(2):107-109

Bhanat E, Koch CA, Parmar R, Garla V, Vijayakumar V. Somatostatin receptor expression in non-classical locations - clinical relevance? Rev Endocr Metab Disord. 2018 Jun;19(2):123-132

Dynkevich Y,Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J. Tumors, IGF-2, and hypoglycemia: insights from the clinic, the laboratory and the historical archive. Endocr Rev 2013;34(6):798-826

Fulop T, Farah Musa AR, Koch CA, Hamrahian M, Gharaibeh K, Lengvarsky Z, Pitman KT, Dixit MP. Targeted surgical parathyroidectomy in end-stage renal disease patients and longterm metabolic control: a single-center experience in the current era. Hemodial Int 2018; Jul;22(3):394-404

Kumar E, McCurdy MT, Koch CA, Hamadah A, Fulop T, Gharaibeh KA. Functional impairment of thyroid function in critically ill patients in the intensive care units. Am J Med Sci 2018; 355(3):281-285

Sindoni A, Fama F, Rosano A, Scisca C, Dionigi G, Koch CA, Gioffre-Florio M, Benvenga S. Thyroid nodules coexisting with either cystic or solid breast nodules: a new clue for this association between nodules coming from ultrasonography. Gland Surg 2017;6(6):630-637

Riley DS, Barber MS, Kienle GS, Aronson J, von Schoen-Angerer T, Tugwell P, Helfand M, Kiene H, Werthmann PG, Shamseer L, Moher D, Rison RA, Koch CA, Hanaway P, Sun GH, Altman DG, Sox H, Sudak N, Gagnier JJ. CARE 2013 explanations and elaborations: reporting guidelines for case reports. J Clin Epidemiol 2017; 89:218-235

Fleseriu M, Findling JW, Koch CA, Schlaffer SM, Buchfelder M, Gross C. Changes in plasma ACTH levels and corticotroph tumor size in patients with Cushing's disease during long-term treatment with the glucocorticoid receptor antagonist mifepristone. J Clin Endocrinol Metab 2014;99(10):3718-27     

Melcescu E, Horton WB, Pitman KT, Vijayakumar V, Koch CA. Euthyroid Graves’ orbitopathy and incidental papillary thyroid microcarcinoma. Hormones (Athens) 2013; Apr 12(2):298-304

Agarwal M, Csongradi E, Koch CA, Juncos LA, Echols V, Tapolyai M, Fulop T. Severe symptomatic hypocalcemia after denusomab administration in an end-stage renal disease patient on peritoneal dialysis with controlled secondary hyperparathyroidism. Br J Med & Med Res 2013;3(4):1398-1406

Gharaibeh KA, Craig MJ, Koch CA, Lerant AA, Fulop T, Csongradi E. Desmopressin for hyponatremia overcorrection: an effective adjunct treatment for reversing rapid overcorrection and preventing osmotic demyelination syndrome. World J Clin Cases 2013;August 16; 1(5):155-158

Melcescu E, Gannon AW, Parent AD, Fratkin JF, Galhom A, Nicholas WC, Koch CA. Silent or subclinical corticotroph pituitary macroadenoma transforming into Cushing’s disease: 11-year follow-up. Neurosurgery 2013;72(1):E144-6 

Saunders RN, Koch CA, Brown KB, Daley WP, Ahmed N, Vanderlan WB. Bilateral adrenal myeolipomas in a woman with chronic anticoagulation, postmenopausal uterine bleeding, primary hyperparathyroidism, and hyperthyroidism. Am J Med Sci 2013; 346(1):82-85

Melcescu E, Hogan RB, Brown K, Boyd SA, Abell TL, Koch CA. The various faces of autoimmune endocrinopathies: non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis.Exp Mol Pathol 2012;93(3):434-40

Phillips J, East HE, French SE, Melcescu E, Hamilton RD, Nicholas WC, Fratkin JF, Parent AD, Luzardo G, Koch CA.  What causes a prolactinoma to be aggressive or to become a pituitary carcinoma? Hormones (Athens) 2012;11(4):477-482

Melcescu E, Phillips J, Moll G, Subauste JS, Koch CA. 11beta-hydroxylase deficiency and other syndromes of mineralocorticoid excess as a rare cause of endocrine hypertension. Horm Metab Res 2012;44(12):867-878  

Fleseriu M, Biller BMK, Findling JW, Molitch ME, Schteingart DE, Gross C on behalf of the SEISMIC study investigators. Mifepristone,  a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing’s syndrome. J Clin Endocrinol Metab 2012 Jun;97(6):2039-49

Singer J, Koch CA, Kassahun W, Lamesch P, Eisenhofer G, Kluge R, Lincke T, Seiwerts M, Borte G, Schierle K, Paschke R. Pitfalls of diagnosis in a patient with a large recurrent pheochromocytoma. Nat Rev Endocrinol 2011;7(12):749-55

Singer J, Werner F, Koch CA, Bartels M, Aigner T, Lincke T, Fasshauer M, Paschke R. Ectopic Cushing’s syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. Exp Clin Endocrinol Diab 2010;118(8):524-9

Majumdar S, Friedrich CA, Koch CA, Megason GC, Fratkin JD, Moll GW. Compound heterozygous mutation with a novel splice donor region DNA sequence variant in the succinate dehydrogenase subunit B gene in a boy with malignant paraganglioma. Pediatr Blood Cancer 2010; 54(3):473-5

Baldauf C, Vortmeyer AO, Koch CA, Sticherling M. Combination of multiple skin malignancies with multiple endocrine neoplasia type 1: coincidental or pathogenetically related? Dermatology 2009;219(4):365-7

Koutlas IG, Koch CA, Vickers RA, Brouwers FM, Vortmeyer AO. An unusual ostensible example of intraoral basal cell carcinoma. J Cut Pathology 2009;36(4):464-70

Anlauf M, Bauersfeld J, Raffel A, Koch CA, et al. Insulinomatosis: a multicentric insulinoma disease that frequently causes early recurrent hyperinsulinemic hypoglycemia. Am J Surg Pathol 2009;33(3):339-46

Georgitsi M, Heliovaara E, Paschke R, Kumar AV, Tischkowitz M, Vierimaa O, Salmela P, Sane T, De Menis E, Cannavo S, Gundogdu S, Lucassen A, Izatt L,Aylwin S, Bano G, Hodgson S, Koch CA, Karhu A, Aaltonen LA. Large genomic deletions of aryl hydrocarbon receptor interacting protein (AIP)gene in pituitary adenoma predisposition. J Clin Endocrinol Metab 2008; 93(10):4146-51

Georgitsi M, Raitila A, Karhu A, van der Luijt RB, Aalfs CM, Sane T, Vierimaa O, Makinen MJ, Tuppurainen K, Paschke R, Gimm O, Koch CA, Gundogdu S, Lucassen A, Tischkowitz M, Izatt L, Aylwin S, Bano G, Hodgson S, De Menis E, Launonen V, Vahteristo P, Aaltonen LA. Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia. J Clin Endocrinol Metab 2007;92(8):3321-5

Brauer VFH, Scholz GH, Neumann S, Lohmann T, Paschke R, Koch CA. RET germline mutation in codon 791 in a family representing 3 generations from age 5 to age 70: should thyroidectomy be performed? Endocr Practice 2004;10(1):5-9

Santarpia L, Koch CA, Sarlis NJ. Hypercalcemia in cancer patients: pathobiology and management. Horm Metab Res 2010; 42(3):153-64  

Koch CA, Fulop T. Clinical aspects of changes in water and sodium homeostasis in the elderly. Rev Endocr Metab Disord 2017;18(1):49-66

Koch CA, Doppman JL, Watson JC, Patronas NJ, Nieman LK. Spinal epidural lipomatosis in a patient with the ectopic corticotropin syndrome. N Engl J Med. 1999 Oct 28;341(18):1399-400

Koch CA, Pacak K, Chrousos GP. The molecular pathogenesis of hereditary and sporadic adrenocortical and adrenomedullary tumors. J Clin Endocrinol Metab 2002; 87: 5367-84

Books

Glasker S, Neumann HPH, Koch CA, Vortmeyer AO. Von Hippel Lindau syndrome. In: Feingold KR1, Anawalt B2, Boyce A3, Chrousos G4, Dungan K5, Grossman A6, Hershman JM7, Kaltsas G8, Koch C9, Kopp P10, Korbonits M11, McLachlan R12, Morley JE13, New M14, Perreault L15, Purnell J16, Rebar R17, Singer F18, Trence DL19, Vinik A20, Wilson DP21, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-2018 Sep 12. PubMed

Endocrine Hypertension (editors: Koch CA & Chrousos GP), Contemporary Endocrinology Series, Springer, New York, 2013, ISBN: 978-1-60761-547-7 (Print), ISBN-10: 978-1-60761-548-4 (online)

Peer-Reviewed Articles

Gubbi S, Hamet P, Tremblay J, Koch CA, Hannah-Shmouni F. Artificial Intelligence and Machine Learning in Endocrinology and Metabolism: The Dawn of a New Era.

Front Endocrinol 2019;   (IF 3.7)

Fulop T, Zsom L, Hamrahian M, Rodriguez RD, Chabrier-Rosello JO, Koch CA. Therapeutic hypernatremia management during continuous renal replacement therapy with elevated intracranial pressures and respiratory failure. Rev Endocr Metab Disord 2019;20 (1):    (IF 4.9)

Koch CA, Krabbe S, Hehmke B. Statins, metformin, proprotein-convertase-subtilisin-kexin type-9 (PCSK9) inhibitors and sex hormones: immunomodulatory properties ? Rev Endocr Metab Disord 2018, Dec (19(4):363-395

Koch CA, Petersenn S. Black swans – neuroendocrine tumors of rare locations. Rev Endocr Metab Disord 2018,Jun;19(2):107-109 (IF 4.9)

Bhanat E, Koch CA, Parmar R, Garla V, Vijayakumar V. Somatostatin receptor expression in non-classical locations - clinical relevance? Rev Endocr Metab Disord. 2018 Jun;19(2):123-132

Fulop T, Koch CA, Norris LT, Rodriguez B, Szarvas T, Csongradi E, Dixit MP. Uric acid control in advanced chronic kidney disease in a Southeast Urban Cohort. South Med J 2018; Sep;111(9):549-555

Fulop T, Farah Musa AR, Koch CA, Hamrahian M, Gharaibeh K, Lengvarsky Z, Pitman KT, Dixit MP. Targeted surgical parathyroidectomy in end-stage renal disease patients and longterm metabolic control: a single-center experience in the current era. Hemodial Int 2018; Jul;22(3):394-404

Kumar E, McCurdy MT, Koch CA, Hamadah A, Fulop T, Gharaibeh KA. Functional impairment of thyroid function in critically ill patients in the intensive care units. Am J Med Sci 2018; 355(3):281-285

Sindoni A, Fama F, Rosano A, Scisca C, Dionigi G, Koch CA, Gioffre-Florio M, Benvenga S. Thyroid nodules coexisting with either cystic or solid breast nodules: a new clue for this association between nodules coming from ultrasonography. Gland Surg 2017;6(6):630-637

Csongrádi E, Káplár M, Nagy Jr  B, Koch CA, Juhász A, Bajnok L, Varga  Z, Seres I, Karányi  Z, Magyar MT, Oláh L, Facskó ,A, Kappelmayer J, Paragh G. Adipokines as atherothrombotic risk factors in obese subjects: associations with haemostatic markers and common carotid wall thickness. Nutr Metab Cardiovasc Dis 2017; 27(6):571-580  (IF 3.4)

Riley DS, Barber MS, Kienle GS, Aronson J, von Schoen-Angerer T, Tugwell P, Helfand M, Kiene H, Werthmann PG, Shamseer L, Moher D, Rison RA, Koch CA, Hanaway P, Sun GH, Altman DG, Sox H, Sudak N, Gagnier JJ. CARE 2013 explanations and elaborations: reporting guidelines for case reports. J Clin Epidemiol 2017; 89:218-235 (IF 4.7)

Ilias I, Venaki E, Nikopoulou S, Koch CA. Glossodynia after osteoporosis treatment. Am J Med Sci 2017;353   (IF 1.5)

Fleseriu M, Findling JW, Koch CA, Schlaffer SM, Buchfelder M, Gross C. Changes in plasma ACTH levels and corticotroph tumor size in patients with Cushing's disease during long-term treatment with the glucocorticoid receptor antagonist mifepristone. J Clin Endocrinol Metab 2014;99(10):3718-27    (IF 6.4)

Gagnier JJ, Kienle G, Altman DG, Moher D, Sox H, Riley D, and the CARE group (incl. Koch C as collaborator). The CARE Guidelines: Consensus-based Clinical Case Report Guideline Development. Global Adv Health Med. 2013;2(5):38-43; Dtsch Arztebl Int. 2013 Sep;110(37):603-8; J Clin Epidemiol 2013; Headache 2013; J Med Case Rep 2013;7:223 doi:10.1186/1752-1947-7-223; BMJ Case Rep. 2013 Oct 23;2013

Ullah MI, Koch CA, Tamanna S, Rouf S, Shamsuddin L. Vitamin D deficiency and the risk of preeclampsia and eclampsia in Bangladesh. Horm Metab Res 2013;45(9):682-7 

Melcescu E, Horton WB, Pitman KT, Vijayakumar V, Koch CA. Euthyroid Graves’ orbitopathy and incidental papillary thyroid microcarcinoma. Hormones (Athens) 2013; Apr 12(2):298-304 (IF 2.4)

Agarwal M, Csongradi E, Koch CA, Juncos LA, Echols V, Tapolyai M, Fulop T. Severe symptomatic hypocalcemia after denusomab administration in an end-stage renal disease patient on peritoneal dialysis with controlled secondary hyperparathyroidism. Br J Med & Med Res 2013;3(4):1398-1406

Gharaibeh KA, Craig MJ, Koch CA, Lerant AA, Fulop T, Csongradi E. Desmopressin for hyponatremia overcorrection: an effective adjunct treatment for reversing rapid overcorrection and preventing osmotic demyelination syndrome. World J Clin Cases 2013;August 16; 1(5):155-158

Melcescu E, Gannon AW, Parent AD, Fratkin JF, Galhom A, Nicholas WC, Koch CA. Silent or subclinical corticotroph pituitary macroadenoma transforming into Cushing’s disease: 11-year follow-up. Neurosurgery 2013;72(1):E144-6  (IF 2.8)

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