Reuters Spotlights Sepsis Research by Dr. Konstantinos Drosatos and Lewis Katz School of Medicine Scientists

Reuters interviewed Konstantinos Drosatos, PhD, Assistant Professor of Pharmacology and Assistant Professor in the Center for Translational Medicine, the Center for Metabolic Disease Research and the Alzheimer’s Center at Temple, about a study recently published online in the journal JCI Insight. The research, conducted by Dr. Drosatos (the senior investigator on the study) and scientists at the Lewis Katz School of Medicine at Temple University, shows that when a molecule known as JNK becomes active in sepsis, it increases the production of a protein called BNP. The more BNP produced in sepsis, the greater deterioration of cardiovascular function. The researchers also showed that, in mice, JNK and BNP can be halted to reverse cardiovascular function and reduce the risk of death from sepsis.