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Media Outlets Highlight Sepsis Research by Dr. Konstantinos Drosatos and Lewis Katz School of Medicine Scientists

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Scientists at the Lewis Katz School of Medicine at Temple University have shown in a new study published online in the journal JCI Insight that when a molecule known as JNK becomes active in sepsis, it increases the production of a protein called BNP. The more BNP produced in sepsis, the greater deterioration of cardiovascular function. The researchers also showed that, in mice, JNK and BNP can be halted to reverse cardiovascular damage and reduce the risk of death from sepsis. Konstantinos Drosatos, PhD, Assistant Professor of Pharmacology and Assistant Professor in the Center for Translational Medicine, the Center for Metabolic Disease Research and the Alzheimer’s Center at Temple, is the senior investigator on the study. Scienmag, Medical Xpress, and News-Medical.net publicized the news.