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Media Outlets Highlight Prostate Cancer Findings from Dr. Xavier Graña-Amat and Team of Lewis Katz School of Medicine and Fox Chase Researchers

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Xavier Graña-Amat, PhD, Professor of Medical Genetics and Molecular Biochemistry, and in the Fels Institute for Cancer Research and Molecular Biology at the Lewis Katz School of Medicine at Temple University (LKSOM), led a research team from LKSOM and Fox Chase Cancer Center that found that patients whose prostate tumors carry only one copy of a tumor suppressor gene known as PPP2R2A do not survive as long as those whose tumors carry two copies of the gene. They also showed that in cells deficient in PPP2R2A, reconstitution of the PP2A protein encoded by the gene ultimately kills prostate cancer cells. The study, published in the journal Oncogenesis, is the first to show that reactivating PP2A in affected cells can slow or stop the advance of prostate cancer in an animal model. Media outlets, including, Technology Networks, Scienmag and Medical Xpress, covered the news.