Seeking Answers and Treatments for Neurologic Diseases

Neurologic diseases are among the most challenging and mysterious conditions facing doctors and their patients today. Temple researchers have made it their life’s mission to unravel the causes of these diseases. Our goal is simple: to develop better tests and more effective treatments for the benefit of our patients with Alzheimer’s disease, Parkinson’s disease, dementia and other neurologic disorders.

Research Focus Areas 

Temple doctors and researchers participate in a wide range of research programs and protocols aimed at advancing the treatment of neurological conditions. Our work spans the basic science laboratories of the Lewis Katz School of Medicine at Temple University to patient bedside. 

Laboratory investigation into the causes and mechanisms of neurological disease takes place in several Temple research centers. Here, scientists work to open the doors to more effective and targeted treatments — from novel pharmaceuticals and biologicals to therapies with genes, stem cells, and medical devices. 

Additionally, Temple doctors and scientists participate in clinical trials, testing the effectiveness of new medications and innovative surgical techniques for treating neurological disorders. Through these clinical trials, we are able to provide patients with access to therapies that aren’t yet available at other centers.

Learn more about our basic sciences and translational neurological research centers at the Lewis Katz School of Medicine:

• The Alzheimer’s Center at Temple
• Center for Neurovirology
• Center for Substance Abuse Research
• Comprehensive NeuroAIDS Center

Ongoing Clinical Trials and Observational Studies

Clinical trials provide opportunities for patients to participate in the latest therapies available before they are commercially available. Observational studies look for new ways to detect disease, and do not include treatments or interventions. Both are an important part of medical advancement. We currently have a number of ongoing clinical trials and observational studies available for patients with neurological conditions:

• Anticoagulation in ICH Survivors for Stroke Prevention and Recovery(ASPIRE)
• Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA)
• A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE2)
• Regulating Blood Pressure During Recovery From Intracerebral Hemorrhage (REDUCE)
• Statins Use in Intracerebral Hemorrhage (SATURN)
• A Study to Evaluate XEN1101 As Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures (X-ACKT)
• A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke (OCEANIC-STROKE)
• A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures
• Sleep for Stroke Management and Recovery Trial (Sleep SMART)
• Follow up After Stroke, Screening and Treatment Clinic (Patient Registry)
   

ALS Clinical Trials and Observational Studies

The MDA/ALS Center of Hope offers several ongoing clinical trials and observational studies. This dedication to research is a core part of the Center and physicians’ commitment to find a cure for ALS. 

ALS Clinical Trials

• HEALEY ALS Platform Trial 
• ROAR-DiGAP 

ALS Clinical Studies

• Philadelphia Amyotrophic Lateral Sclerosis (PALS) Cohort Respiratory Study
• PLS Natural History Study
• Natural History of ALS/MND
• Tissue Bank
• MDA/MOVR Data Hub
• Evaluation of GI Symptoms in ALS
• Assessing Assistive Technology Use and Needs

For more information about clinical trials and observational studies at the Temple Neurosciences Center, please ask your physician.